FREDERICK B. ROSE, M.D.; CAROL J. CAMP, M.S.; MICHAEL CHISDAK, M.D.
To the editor: We read with interest the article by Wheat and associates concluding that age greater than 54 years and immuno-suppression were the only risk factors for disseminated or fatal histoplasmosis (1). In view of the increased risk of overwhelming bacterial disease in asplenic patients (2-5), we question whether asplenism may contribute also to dissemination of fungal disease. Recently we cared for a surgically asplenic but otherwise healthy man who presented with a perplexing long-term fever of undetermined origin until Histoplasma capsulatum was isolated from bone marrow and blood cultures.
On 24 September 1980, a 29-year-old truckdriver sustained minor
ROSE FB, CAMP CJ, CHISDAK M. Disseminated Histoplasmosis and Asplenia. Ann Intern Med. ;96:790. doi: 10.7326/0003-4819-96-6-790_1
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Published: Ann Intern Med. 1982;96(6_part_1):790.
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