G. ARTHUR VAN VOOLEN, M.D.; H. RICHARD HELLSTROM, M.D.; DOUGLAS A. NELSON, M.D.
To the editor: Because paroxysmal nocturnal hemoglobinuria has been associated with primary myelofibrosis and myeloid metaplasia, has occurred concomitantly with erythroleukemia, and has terminated in acute myeloblastic leukemia (1) and acute myelomonoblastic leukemia (2), it has been considered a "candidate" myeloproliferative disorder (3).
However, only three studies have been reported in which the paroxysmal-nocturnal-hemoglobinuria-like defect has been systematically sought in a series of patients with any form of myeloproliferative syndrome, and results have been variable. Of 50 patients with polycythemia vera, primary myelofibrosis and myeloid metaplasia, and the subtypes of acute myeloblasts leukemia reported by Catovsky and associates (4), none
VAN VOOLEN GA, HELLSTROM HR, NELSON DA. Paroxysmal Nocturnal Hemoglobinuria and the Myeloproliferative Syndrome. Ann Intern Med. ;96:792. doi: 10.7326/0003-4819-96-6-792
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Published: Ann Intern Med. 1982;96(6_part_1):792.
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