ANDREW C. BRAUDE, M.B., Ch.B; ANTHONY S. REBUCK, M.D.
High-dose corticosteroid therapy is used in various lung diseases, yet it is not known if the drug enters the alveolar acinus. Cortisol levels, expressed as a function of albumin concentration, were measured in serum and bronchoalveolar lavage fluid in 12 patients with lung disease. There was a linear relation of Cortisol concentration between blood level and bronchoalveolar lavage fluid level when expressed in relation to the albumin concentration (r=0.93,p< 0.001). Incremental doses of intravenous hydrocortisone reach alveolar structures in a concentration directly related to the circulating blood levels.
ANDREW C. BRAUDE, ANTHONY S. REBUCK. Pulmonary Disposition of Cortisol. Ann Intern Med. 1982;97:59–60. doi: 10.7326/0003-4819-97-1-59
Download citation file:
Published: Ann Intern Med. 1982;97(1):59-60.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use