ANDREW C. BRAUDE, M.B., Ch.B; ANTHONY S. REBUCK, M.D.
High-dose corticosteroid therapy is used in various lung diseases, yet it is not known if the drug enters the alveolar acinus. Cortisol levels, expressed as a function of albumin concentration, were measured in serum and bronchoalveolar lavage fluid in 12 patients with lung disease. There was a linear relation of Cortisol concentration between blood level and bronchoalveolar lavage fluid level when expressed in relation to the albumin concentration (r=0.93,p< 0.001). Incremental doses of intravenous hydrocortisone reach alveolar structures in a concentration directly related to the circulating blood levels.
BRAUDE AC, REBUCK AS. Pulmonary Disposition of Cortisol. Ann Intern Med. ;97:59–60. doi: 10.7326/0003-4819-97-1-59
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Published: Ann Intern Med. 1982;97(1):59-60.
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