BALDEV S. SANDHU, M.B., CH.B.; RAMIRO REQUENA, M.D.
To the editor: Cimetidine (Tagamet; Smith Kline & French, Philadelphia, Pennsylvania), a specific H2 receptor antagonist, has been widely used in medical practice with remarkably few adverse reactions (1) since its introduction in 1976. In 1981, Sawyer and associates published "Cimetidine: Adverse Reactions and Acute Toxicity" (2), containing approximately 100 reports of acute Cimetidine toxicity; there was no mention of any report of type I hypersensitivity. Our review of the literature showed one previous report (3) of a type I hypersensitivity response to Cimetidine in which a 35-year-old woman developed facial edema, laryngospasm and dyspnea related to Cimetidine administration. The
SANDHU BS, REQUENA R. Hypersensitivity to Cimetidine. Ann Intern Med. ;97:138. doi: 10.7326/0003-4819-97-1-138_2
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Published: Ann Intern Med. 1982;97(1):138.
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