ROBERT L. BARBIERI, M.D.
To the editor: The recent review of danazol by Madanes and Farber (1) is an excellent summary of the drug's properties. However, there are a few substantive errors that need correction.
Madanes and Farber state than danazol inhibits adrenal 16α-hydroxylase. The paper (2) they cite to support this statement does not examine the effects of danazol on 16α-hydroxylase, and other unpublished reports have shown that danazol does not inhibit 16α-hydyroxylase. The authors state that danazol inhibits microsomal and mitochondrial cytochrome P-450 in cultured adrenal tissue. In fact, the experiments cited were done on isolated mitochondrial and microsomal fractions in vitro
BARBIERI RL. Danazol. Ann Intern Med. 1982;97:286. doi: 10.7326/0003-4819-97-2-286_1
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Published: Ann Intern Med. 1982;97(2):286.
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