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No concept in renal physiology has been as revolutionary as the loop of Henle as a countercurrent system responsible for urine concentration. The idea was introduced in 1942 by Werner Kuhn, a Swiss physical chemist who had earlier worked on a countercurrent system for the purification of heavy water. Kuhn and his colleagues went on to provide experimental verification in 1951. The theory is now so universally accepted that it is easy to forget the initial astonishment and doubts it engendered in a field dominated by Homer Smith and his disciples, who pictured the nephron with its loops ironed out
Urinary Concentrating Mechanism. Structure and Function.. Ann Intern Med. 1982;97:296. doi: 10.7326/0003-4819-97-2-296_1
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Published: Ann Intern Med. 1982;97(2):296.
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