ARLENE A. MCLEAN, PH.D.; RAYMOND SHAW JR., PH.D.
To the editor: The paper by Francis and associates (1) in this issue shows the safety and efficacy of inactivated hepatitis B vaccine in a large multi-center trial. A disturbing finding is the lower than expected immunogenicity of the vaccine. Factors that could affect the potency of the vaccine were carefully examined. The purpose of this letter is to summarize those findings.
Our investigations centered on the shipment and storage conditions of the vaccine, for three reasons. First, it has been shown that male homosexuals respond well to 20-µg doses of vaccine (SZMUNESS W, STEVENS CE. Personal communication). Second, vaccine
MCLEAN AA, SHAW R. Hepatitis B Virus Vaccine. Ann Intern Med. ;97:451. doi: 10.7326/0003-4819-97-3-451_1
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Published: Ann Intern Med. 1982;97(3):451.
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