DAVID CUNDIFF, M.D.
To the editor: The National Cooperative Gallstone Study Group report (1) concluded that "chenodiol has a role in the treatment of selected patients with gallstones." A review of the data from that study suggests just the opposite conclusion.
Patients receiving chenodiol had no fewer episodes of biliary cholic. Cholecystectomies were needed in 4.3% of the placebo group, 6.1% of the high-dose chenodiol group, and 9.0% of the low-dose chenodiol group (low-dose), p < 0.030 versus placebo). Survival was not influenced in the short follow-up period.
Although treated patients were not better off in terms of symptoms, disease complications, or survival,
CUNDIFF D. Chenodiol and Gallstones. Ann Intern Med. ;97:452–453. doi: 10.7326/0003-4819-97-3-452_2
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Published: Ann Intern Med. 1982;97(3):452-453.
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