PHILIP J. MEASE, M.D.; ALLAN J. ELLSWORTH, PHARM.D.; PAUL D. KILLEN, M.D.; ROBERT F. WILLKENS, M.D.
To the editor: We report severe renal failure and nephrotic syndrome in three patients taking zomepirac sodium, a nonsteroidal anti-inflammatory drug.
A 46-year-old woman who had been taking zomepirac sodium for 2 months for headache developed renal failure and nephrotic syndrome. Laboratory studies showed creatinine, 3.9 mg/dL; blood urea nitrogen, 90 mg/dL; albumin, 1.4 mg/dL; and 24-hour urine protein, 14.5 g. Renal biopsy showed tubular cell vacuolization with sloughing of tubular cells and interstitial edema with a pleomorphic infiltrate. Results of immunofluorescent studies were normal. Zomepirac was withdrawn and prednisone, 60 mg/d, was instituted. Renal failure and nephrotic syndrome resolved
MEASE PJ, ELLSWORTH AJ, KILLEN PD, WILLKENS RF. Zomepirac, Interstitial Nephritis, and Renal Failure. Ann Intern Med. ;97:454. doi: 10.7326/0003-4819-97-3-454_1
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Published: Ann Intern Med. 1982;97(3):454.
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