DAVID KAPLAN, M.D.
To the editor: The report by Dinant and colleagues (1) describing different drug therapies for lupus nephritis contains two important lessons in addition to being an example of a welldesigned clinical trial.
The "prednisone only" group apparently received about 20 to 30 mg of prednisone per day (0.3 to 0.4 mg/kg body weight · d), which would be considered grossly inadequate treatment by many. Yet these patients did remarkably well. The dangers of using retrospective controls (2) or comparing data between different centers are well demonstrated.
If cytotoxic drugs are marginally better than inadequate treatment, one might wonder about the
KAPLAN D. Therapies for Lupus Nephritis. Ann Intern Med. ;97:454. doi: 10.7326/0003-4819-97-3-454_2
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Published: Ann Intern Med. 1982;97(3):454.
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