ALLAN R. GLASS, M.D.; RIPLEY BALLOU, M.D.
To the editor: In his excellent review of prazosin, Colucci (1) indicates that severe hypotension after the initial dose of prazosin ("first-dose phenomenon") is extremely rare if this dose is 1 mg or less. He also points out the usefulness of prazosin in the treatment of pheochromocytoma. However, his reference for this latter point (2) is the report of only one patient, who in fact did have a severe hypotensive response to an initial prazosin dose of only 1 mg. We also saw a patient with pheochromocytoma who developed severe hypotension in response to an initial prazosin dose of 1
GLASS AR, BALLOU R. Pheochromocytoma, Prazosin, and Hypotension. Ann Intern Med. ;97:455. doi: 10.7326/0003-4819-97-3-455_2
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Published: Ann Intern Med. 1982;97(3):455.
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