HERVÉ LIGNIAN, M.D.; JEANINE FONTAINE, M.D.; ROBERT ASKENASI, M.D.
To the editor: In a recent article, Lyon and Antony (1) reported the dramatic effect of naloxone hydrochloride in two comatose patients with alcoholic intoxication. They stress, for the first time, the need to repeat injections to keep the patients awake. Their data favour the hypothesis that endorphins play a role in the alcoholic coma.
However, in our experience, only 10% of the patients in coma improve after naloxone administration. Our impression is corroborated by the work of Jefferys and associates (2), which indicates the presence of an individual sensitivity to endorphins in some patients with acute alcoholic intoxication.
LIGNIAN H, FONTAINE J, ASKENASI R. Naloxone and Alcoholic Intoxication. Ann Intern Med. ;97:455–456. doi: 10.7326/0003-4819-97-3-455_3
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Published: Ann Intern Med. 1982;97(3):455-456.
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