OKSANA KORZENIOWSKI, M.D.; MERLE A. SANDE, M.D.
Single (nafcillin for 6 weeks) and combined (nafcillin for 6 weeks plus gentamicin for 2 weeks) drug regimens were compared in two separate multicenter prospective randomized trials. Forty-eight parenteral drug addicts and 30 nonaddicts with clinically and bacteriologically documented Staphylococcus aureus endocarditis were studied. In the addicts, combined therapy effected a more rapid mean clinical response (defervescence and normalization of leukocyte count) and a reduced duration of bacteremia in patients with right-sided endocarditis. In the nonaddicts, combined therapy effected more rapid clearance of bacteremia, but was associated with a higher incidence of azotemia. The addition of gentamicin did not alter morbidity or mortality in either group.
KORZENIOWSKI O, SANDE MA. Combination Antimicrobial Therapy for Staphylococcus aureus Endocarditis in Patients Addicted to Parenteral Drugs and in Nonaddicts: A Prospective Study. Ann Intern Med. ;97:496–503. doi: 10.7326/0003-4819-97-4-496
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Published: Ann Intern Med. 1982;97(4):496-503.
Cardiology, Endocarditis, Infectious Disease.
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