CHARLES H. CROFT, M.D.; BRIAN G. FIRTH, M.D.; D. Phil.; L. DAVID HILLIS, M.D.
Amphetamine abuse has previously been implicated in the pathogenesis of congenital heart disease (1), necrotizing vasculitis (2), intracranial hemorrhage (3), pulmonary fibrosis, and cor pulmonale (4). Although animal studies have shown a relation between myocardial amphetamine concentrations and toxicity (5), only one patient has been described in whom the chronic use of oral dextroamphetamine was associated with a cardiomyopathy (6). We describe four patients with severe left ventricular dysfunction in association with chronic abuse of the amphetamine analog, propylhexedrine.
Between September 1978 and February 1982, four men who were chronic abusers of intravenous propylhexedrine (Benzedrex, Smith Kline & French Laboratories,
CROFT CH, FIRTH BG, HILLIS LD. Propylhexedrine-Induced Left Ventricular Dysfunction. Ann Intern Med. ;97:560–561. doi: 10.7326/0003-4819-97-4-560
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Published: Ann Intern Med. 1982;97(4):560-561.
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