KEVIN R. BROWN, PHARM. D.; B. JOSEPH GUGLIELMO, PHARM. D.; VINCENT G. PONS, M.D.; RICHARD A. JACOBS, M.D.
To the editor: A "disulfiram-like" reaction has been associated with certain new cephalosporins including moxalactam (1-5). This case report shows the serious nature of the reaction in a hospitalized patient who was receiving moxalactam and elixir of theophylline.
A 75-year-old man had surgery for removal of an infected aortofemoral bypass graft and revascularization. The surgery was well tolerated but the postoperative course was complicated by several episodes of acute respiratory insufficiency needing intubation, recurrent sepsis, and acute tubular necrosis. After one septic episode, moxalactam was started. After 6 days of therapy, the patient was markedly improved. He requested and received
BROWN KR, GUGLIELMO BJ, PONS VG, JACOBS RA. Theophylline Elixir, Moxalactam, and a Disulfiram Reaction. Ann Intern Med. ;97:621–622. doi: 10.7326/0003-4819-97-4-621_2
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Published: Ann Intern Med. 1982;97(4):621-622.
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