LEO R. ZACHARSKI, M.D.
To the editor: The information in the recent letter by Krauss (1) is misleading on three counts and calls for a response. Krauss suggests that prolonged warfarin anticoagulation may predispose to cancer. In fact, there was no increase in the incidence of malignancy seen in two cohorts of patients that had received long-term anticoagulant treatment and had been followed for several thousand patient-years (2, 3).
Second, Krauss' use of the term "teratogen" referring to the effects of warfarin on the fetus is correct in that the drug causes developmental abnormalities in the fetus referred to as warfarin embryopathy. I am
ZACHARSKI LR. Warfarin and Cancer. Ann Intern Med. ;97:784. doi: 10.7326/0003-4819-97-5-784_2
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Published: Ann Intern Med. 1982;97(5):784.
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