JAMES T. JAKES, M.D.; EDMUND L. DUBOIS, M.D.; FRANCISCO P. QUISMORIO JR., M.D.
To the editor: We read with interest the article describing the dramatic response to dapsone therapy of bullous eruptions in patients with systemic lupus erythematosus (1). We report our use of dapsone and another antileprosy drug, clofazimine, in an open trial for the treatment of mucocutaneous lesions in patients with systemic lupus erythematosus and discoid lupus erythematosus who were resistant to conventional antimalarial treatment or who needed continued systemic corticosteroid therapy. Clofazimine has been reported to be effective in the treatment of discoid lupus erythematosus (2, 3).
Seven patients were given dapsone at a starting dose of 50 mg/d. This
JAKES JT, DUBOIS EL, QUISMORIO FP. Antileprosy Drugs and Lupus Erythematosus. Ann Intern Med. ;97:788. doi: 10.7326/0003-4819-97-5-788_2
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Published: Ann Intern Med. 1982;97(5):788.
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