WILLIAM HOROWITZ, M.D.
To the editor: I take exception to the title, "Familial Chronic Mononucleosis," of the excellent article by Ballow and associates (1). In the discussion section, the paper is described as "the first report of familial chronic mononucleosis in association with mild variable immune abnormalities." By definition, infectious mononucleosis is an acute infection accompanied by irregular fever, severe pharyngitis, adenopathy, splenomegaly, and has characteristic laboratory findings: an absolute lymphocytosis with many "atypical" cells, antibodies against heterologous erythrocytes, and rising titers against the Epstein-Barr virus (2).
The family as described has a mild immune deficiency disorder plus abnormal results of serologic studies
WILLIAM HOROWITZ. What is Mononucleosis?. Ann Intern Med. 1983;98:415. doi: 10.7326/0003-4819-98-3-415_1
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Published: Ann Intern Med. 1983;98(3):415.
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