BRIAN L. BOTTEMILLER, R.PH.; GARY C. NICHOLAS, R.PH.
To the editor: We read with some bewilderment the transcript of the UCLA Conference on the diagnosis and treatment of epilepsy(1). The section on pharmacologic therapy contained some statements by Dr. Troupin that are either misleading or untrue.
The statement that one must dose a drug every half-life or more often to reach a steady state is untrue. As the author states elsewhere in the text, the time to reach steady state depends only on the drug's half-life. In all instances, with drugs that show first-order kinetics (more than 90% of drugs), steady state is reached in five half-lives. Because
BOTTEMILLER BL, NICHOLAS GC. Drug Dose and Pharmacokinetics. Ann Intern Med. ;98:418. doi: 10.7326/0003-4819-98-3-418_2
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Published: Ann Intern Med. 1983;98(3):418.
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