LINDA A. HERSHEY, M.D., PH.D.
Kaiko and associates (1) have recently reported in Annals of Neurology on the excitatory effects in the central nervous system of meperidine. Of 67 patients with cancer who received this drug for relief of postoperative or chronic pain, 48 had agitation, tremors, myoclonus, or seizures while taking meperidine (for further details, see the abstract reprinted in the "From Other Pages" section this month). The findings in this elegant study illustrate several important principles of clinical pharmacology.
An active metabolite of a drug is sometimes as likely to cause an adverse drug reaction as the parent drug itself. Kaiko and associates
HERSHEY LA. Meperidine and Central Neurotoxicity. Ann Intern Med. 1983;98:548–549. doi: 10.7326/0003-4819-98-4-548
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Published: Ann Intern Med. 1983;98(4):548-549.
Emergency Medicine, Neurology.
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