KIRK J. RODYSILL, M.D.; J. BRYAN WARREN, M.D.
To the editor: Toxic psychosis associated with the use of belladonna alkaloids is well documented (1). Transdermal scopolamine (Transderm-V; Ciba-Geigy Corp., Summit, New Jersey) is now available for treatment of motion sickness. Transdermal administration has been reported to prevent many of the adverse effects associated with oral scopolamine (2). We report a case of a patient with toxic delerium associated with transdermal scopolamine.
Transdermal scopolamine, 0.5 mg, was prescribed for a 76-year-old woman with persistent vertigo and nausea after she had herpes zoster oticus. Approximately 8 hours after applying a patch without removing one already in place, the patient developed
RODYSILL KJ, WARREN JB. Transdermal Scopolamine and Toxic Psychosis. Ann Intern Med. ;98:561. doi: 10.7326/0003-4819-98-4-561_2
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Published: Ann Intern Med. 1983;98(4):561.
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