BARRY A. WARNER, D.O.
To the editor: Having recently seen a 6-year-old child with propylthiouracil-induced agranulocytosis, I read the recent article by Cooper and colleagues (1) with great interest. Unfortunately, this short literature review of 50 patients omitted a 1981 Japanese study that casts serious doubts on several of the paper's conclusions (2).
Hamada and associates reported data on ten patients with methimazole-induced agranulocytosis. Four of these patients were younger than age 30 years; all received 30 mg or less of methimazole; and one patient, a 16-year-old girl, died of hemorrhage after tonsillar necrosis. By not including this data, a number of misconceptions have
WARNER BA. The Medical-Literature System: Gold or Gold-Plated?. Ann Intern Med. ;98:562. doi: 10.7326/0003-4819-98-4-562
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Published: Ann Intern Med. 1983;98(4):562.
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