LODOVICO BALDUCCI, M.D.; DIANA D. LITTLE, R.N., B.S.N.; NANCY G. GLOVER, R.D.; CHERYL S. HARDY, Ph.D.; MARTIN H. STEINBERG, M.D.
Drug-induced myelotoxicity is a major limiting factor in effective cancer treatment (1). Cancer and protein calorie malnutrition associated with cancer may cause hematopoietic depression and enhance the myelotoxicity of cycle-active antineoplastic agents (2, 3).
Granulocytopoiesis, which is commonly affected by chemotherapy, may be estimated by measuring the granulocyte reserve (4). We compared the granulocyte reserve of malnourished and well nourished patients with and without associated cancer to establish whether malnutrition and cancer are independent factors affecting granulocyte reserve.
Forty one men, ages 49 to 74 years, were studied, 24 of whom were malnourished. Twenty-one patients had metastatic cancer, 13 of
BALDUCCI L, LITTLE DD, GLOVER NG, HARDY CS, STEINBERG MH. Granulocyte Reserve in Cancer and Malnutrition. Ann Intern Med. ;98:610–611. doi: 10.7326/0003-4819-98-5-610
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Published: Ann Intern Med. 1983;98(5_Part_1):610-611.
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