DAVID SHIMM, M.D.; GERALD LOGUE, M.D.
The value of the randomized trial for the evaluation of new cancer therapies is undisputed. However, because such trials often do not accrue sufficient numbers of patients in a period of time short enough to be practical (especially when the disease under study is not particularly common), investigators often resort to alternatives to the randomized control group.
Several recently published clinical studies using chemotherapy for patients with solid tumors have reported survival data by comparing the actuarial survival of patients responding to chemotherapy to the survival of patients not responding to chemotherapy (1-3). Invariably, patients who respond survive longer than
SHIMM D, LOGUE G. Analysis of Survival in Cancer Clinical Trials. Ann Intern Med. ;98:665–666. doi: 10.7326/0003-4819-98-5-665
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Published: Ann Intern Med. 1983;98(5_Part_1):665-666.
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