A.A.-B. BADAWY, M.D.; M. EVANS, M.D.
To the editor: An article (1) and a recent letter (2) have emphasized both the usefulness of naloxone in the treatment of acute alcohol intoxication and our poor understanding of how this opiate-receptor antagonist acts. One possible mechanism of action of naloxone is that of pharmacokinetic antagonism of acute alcohol intoxication. This is based on our findings (3) that intraperitoneal administration to rats of naloxone hydrochloride (1 mg/kg body weight) 1.5 hours after a similar injection of ethanol (2 g/kg body weight) causes, within 30 minutes, a decrease in blood ethanol concentration from 133 to 92 mg/ dL, and a
BADAWY A, EVANS M. Naloxone in Ethanol Intoxication. Ann Intern Med. ;98:672. doi: 10.7326/0003-4819-98-5-672_2
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Published: Ann Intern Med. 1983;98(5_Part_1):672.
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