DANIEL E. CASEY, M.D.
To the editor: Additional information on the neurologic side effects of metoclopramide should be added to the review of Albibi and McCallum (1). Because metoclopramide blocks dopamine receptors and produces behavioral and biochemical signs of receptor hypersensitivity (2), it probably is similar to other neuroleptics in causing drug-induced dyskinesias.
Of primary concern is the capacity of prolonged metoclopramide use to produce tardive dyskinesia, a potentially irreversible syndrome of abnormal involuntary movements that occurs more frequently with increasing age and may not be evident until the drug is discontinued. Although the first case of metoclopramide-associated tardive dyskinesia occurred in a patient
CASEY DE. Metoclopramide Side Effects. Ann Intern Med. ;98:673–674. doi: 10.7326/0003-4819-98-5-673_3
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Published: Ann Intern Med. 1983;98(5_Part_1):673-674.
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