FRANCES SANDLER SILVER, M.D.; LUIS R. ESPINOZA, M.D.; ROBERT C. HARTMANN, M.D.
To the editor: Acral erythema or Raynaud's phenomenon has been described in patients on various chemotherapeutic regimens, notably those including bleomycin and vinblastine (1-3). An adjuvant role for cispiatin and for smoking has also been suggested (1). Burgdorf and associates (4) have described a patient with acute myeloid leukemia who developed acral erythema while on a chemotherapeutic regimen that did not include bleomycin or vinblastine but consisted of cytarabine, doxorubicin, and vincristine (4). We recently saw a patient who developed acral erythema but whose only chemotherapeutic drug was hydroxyurea and whose symptoms recurred with a second use of the drug.
SILVER FS, ESPINOZA LR, HARTMANN RC. Acral Erythema and Hydroxyurea. Ann Intern Med. ;98:675. doi: 10.7326/0003-4819-98-5-675_2
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Published: Ann Intern Med. 1983;98(5_Part_1):675.
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