ALAN R. RUSHTON, M.D., PH.D.
To the editor: Cimetidine is a histamine H2 receptor antagonist widely used to decrease gastric acid secretion in ulcer disease. Hallucinations, confusion, and agitation have been reported in persons with renal or hepatic dysfunction that prevents normal drug excretion and allows toxic levels to accumulate in the blood and cerebrospinal fluid (1). Acute psychosis developed in a girl with an underlying metabolic disorder who accidentally took Cimetidine. Her behavior may be explained by the effect of the drug on the aberrant H2 receptor system in her brain tissue.
A 16-year-old girl with pseudohypoparathyroidism had decreased serum levels of ionized calcium,
RUSHTON AR. Pseudohypoparathyroidism, Cimetidine, and Neurologic Toxicity. Ann Intern Med. ;98:677. doi: 10.7326/0003-4819-98-5-677_2
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Published: Ann Intern Med. 1983;98(5_Part_1):677.
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