SAMUEL RAPOPORT, M.D., PH.D.; PAMELA ZYMAN, M.D.
To the editor: Neurologic complications of captopril have only been reported to affect the peripheral nervous system (1, 2). We treated a patient who developed encephalopathy and worsening of focal neurologic signs after beginning treatment with captopril for hypertension.
A 62-year-old man presented for evaluation of right-sided weakness, slurred speech, and ataxia with falling to the right, which developed over a week and began after he had taken five 25-mg doses of captopril. His wife had monitored his blood pressure at home during the week before hospitalization and noted no decrease below 140/80 mm Hg.
His medical history included neurofibromatosis
RAPOPORT S, ZYMAN P. Captopril and Central Nervous System Effects. Ann Intern Med. ;98:1023. doi: 10.7326/0003-4819-98-6-1023_1
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Published: Ann Intern Med. 1983;98(6):1023.
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