G. MAZZACCA, M.D.; A. D'ARIENZO, M.D.; G. AMBROGIO, M.D.
To the editor: Albibi and McCallum (1) recently reviewed the pharmacologic aspects and clinical applications of metoclopramide. They mentioned that the drug increases plasma aldosterone levels. We should like to point out that this effect also can be elicited in clinical conditions with secondary hyperaldosteronism, such as liver cirrhosis with ascites. In 15 patients with ascites due to cirrhosis of the liver and with high serum aldosterone levels (288 ± 74 pg/mL), we found that a parenteral bolus of 10 mg of metoclopramide caused a further statistically significant increase of the hormonal serum concentrations (354 ± 90 pg/mL; p <
MAZZACCA G, D'ARIENZO A, AMBROGIO G. Metoclopramide and Secondary Hyperaldosteronism. Ann Intern Med. 1983;98:1024–1025. doi: 10.7326/0003-4819-98-6-1024_2
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Published: Ann Intern Med. 1983;98(6):1024-1025.
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