H. JEFFREY LAWRENCE, M.D.; SCOTT H. GOODNIGHT JR., M.D.
To the editor: Extravasation of anthracycline chemotherapeutic agents into subcutaneous tissues is a feared complication of cancer treatment. Immediate maneuvers to prevent or reduce tissue necrosis include application of ice packs; local instillation of sodium bicarbonate, corticosteroids, or both together; and early surgical debridement (1, 2). Unfortunately, tissue necrosis often occurs despite these efforts. Desai and Teres (3) recently reported from a controlled study that topical dimethyl sulfoxide prevented tissue necrosis after intradermal injections of doxorubicin in Spraque-Dawley rats. This experimental observation has not been confirmed by others (DORR RT. Unpublished observation).
We recently observed a possible beneficial effect of
LAWRENCE HJ, GOODNIGHT SH. Dimethyl Sulfoxide and Extravasation of Anthracycline Agents. Ann Intern Med. ;98:1025. doi: 10.7326/0003-4819-98-6-1025_1
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Published: Ann Intern Med. 1983;98(6):1025.
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