STEPHEN J. W. EVANS, M.SC.; THOMAS D. WALSH, M.SC.
To the editor: Problems of group differences inherent in traditional randomisation techniques highlighted in the editorial by Braitman (1) can be overcome by sophisticated randomisation procedures, which he did not address. Minimisation (2) assigns subjects entering a controlled trial to either group such as to ensure the best balance between the test/control groups at that point in time. It is particularly suited to the conduct of clinical trials in complex situations; we are using it in a controlled study of Imipramine as an adjuvant analgesic to morphine in pain due to advanced cancer. The criteria on which randomisation by this
EVANS SJW, WALSH TD. Randomization Procedures. Ann Intern Med. ;99:277. doi: 10.7326/0003-4819-99-2-277_1
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Published: Ann Intern Med. 1983;99(2):277.
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