J. GLENN MORRIS JR., M.D.; JAMES H. TENNEY, M.D.
To the editor: A recent article on methicillin-resistant Staphylococcus aureus endocarditis by Levine and associates (1) suggested that combination therapy with rifampin and vancomycin should be used with caution, in part because of the in-vitro antagonism which has been noted between the two drugs (2, 3). We report a case of methicillin-resistant S. aureus endocarditis in which in-vitro antagonism was present, but in which an apparent bacteriologic cure was obtained only after therapy with both rifampin and vancomycin.
A 73-year-old man with a prosthetic aortic valve became febrile (103.6 °F) 24 hours after a transurethral resection (for which he had
MORRIS JG, TENNEY JH. Methicillin-Resistant Staphylococcus aureus. Ann Intern Med. ;99:283–284. doi: 10.7326/0003-4819-99-2-283_3
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Published: Ann Intern Med. 1983;99(2):283-284.
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