CRAIG A. ELMETS, M.D.
Immunopathologic assessment of antibody and complement deposition in the skin has become an essential procedure in the diagnosis of cutaneous diseases such as lupus erythematosus, pemphigus, bullous pemphigoid, and cutaneous vasculitis. The in-situ characterization of mononuclear cells in inflammatory and neoplastic infiltrates of the skin should be an equally important probe for the analysis of other cutaneous and systemic disorders. This new ability to identify mononuclear cell subsets in histologic sections of skin results largely from the production of monoclonal antibodies that segregate subpopulations of immunocompetent cells with distinct cell surface markers. Although phenotypic markers do not always correlate with
ELMETS CA. Phenotypic Characterization of Cutaneous Infiltrates. Ann Intern Med. 1983;99:406–407. doi: 10.7326/0003-4819-99-3-406
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Published: Ann Intern Med. 1983;99(3):406-407.
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