DOUGLAS W. BLAYNEY, M.D.; PRASHANT K. ROHATGI, M.D.; WILLIAM HINES, M.D.; MARJORIE ROBERT-GUROFF, PH.D.; W. CARL SAXINGER, PH.D.; WILLIAM A. BLATTNER, M.D.; ROBERT C. GALLO, M.D.
To the editor: We have recently described the "sentinel disease" of infection with the human T-cell leukemia virus (HTLV) as adult T-cell leukemia (1). We were struck by the clinical similarity between adult T-cell leukemia and the nonmalignant disease of unknown cause, Boeck's sarcoid. Both diseases are characterized by lymphadenopathy, lesions, circulating abnormal lymphocytes, and hypercalcemia, and both probably cluster in the southeastern United States. We hypothesized that Boeck's sarcoid (sarcoidosis) may be a nonmalignant result of infection with the human retrovirus, HTLV, because of animal retrovirus models (where primary infection results in differing clinical manifestations), the similarity in clinical
BLAYNEY DW, ROHATGI PK, HINES W, ROBERT-GUROFF M, SAXINGER WC, BLATTNER WA, et al. Sarcoidosis and the Human T-cell Leukemia-Lymphoma Virus. Ann Intern Med. ;99:409. doi: 10.7326/0003-4819-99-3-409_1
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Published: Ann Intern Med. 1983;99(3):409.
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