H. THOMAS FOLEY, M.D., J.D.; ROBERT F. DONOHOE, M.D.
To the editor: In a recent editorial Dr. Comstock (1) recommends seriously considering a 1-year course of "carefully monitored preventive treatment with isoniazid" for patients who have "fibrotic lesions of the lungs that are consistent with tuberculosis, and who have not completed a full course of anti-tuberculosis chemotherapy." This recommendation is based on a recent clinical study that showed a 93% reduction in the development of active tuberculosis in the treated group over a 5-year period when compared with that in the placebo group(2). However, examination of the data upon which his recommendation is founded shows that this impressive 93%
FOLEY HT, DONOHOE RF. Prevention of Tuberculosis with Isoniazid. Ann Intern Med. 1983;99:409–410. doi: 10.7326/0003-4819-99-3-409_2
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Published: Ann Intern Med. 1983;99(3):409-410.
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