JAY A. GOLDSTEIN, M.D.
To the editor: For 2 years I have been treating patients in my family practice who have mononucleosis with cimetidine, 300 mg three times a day for 5 days. Twenty-nine of thirty-two patients have had almost complete remission of symptoms in 1 or 2 days, and in no patient has the disease recurred. There have been no adverse effects and no complications.
Because herpes virus disorders may cause excessive suppressor T-cell activity (1) and because suppressor T cells have H-2 receptors, (2) this excessive activity may be partially blocked by cimetidine. Suppressor T cells may secrete lymphokines that may be
GOLDSTEIN JA. Cimetidine and Mononucleosis. Ann Intern Med. ;99:410–411. doi: 10.7326/0003-4819-99-3-410_2
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Published: Ann Intern Med. 1983;99(3):410-411.
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