CHARLES WISEMAN, M.D.
To the editor: The recent report by Poon and associates (1) provides additional evidence associating antigens of mouse mammary tumor virus with human breast cancer. However, a number of questions should be raised regarding details of the methods in their study.
The authors state that their patient, a laboratory worker, had in the past been a negative control but unexpectedly developed a positive reactivity. Nine months later, she developed breast cancer. The authors do not tell us if the patient was resampled, or if the positive specimen was reproducibly reactive, or to what titer was this reactivity identifiable. In normal
WISEMAN C. Breast Cancer and Mouse Mammary Tumor Virus. Ann Intern Med. ;99:411. doi: 10.7326/0003-4819-99-3-411_2
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Published: Ann Intern Med. 1983;99(3):411.
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