WILLIAM O. FRANK, M.D.; JOHN J. SEAMAN, D.P.; KARL E. PEACE, PH.D.; RALPH M. MYERSON, M.D.; THOMAS J. HUMPHRIES, M.D.
To the editor: Knapp and associates (1) recently reported 15 patients who were treated with cimetidine and lidocaine concomitantly, and the authors concluded that there was an interaction between cimetidine and lidocaine. We are concerned, however, that the results supporting the authors' conclusions may be open to serious question because of several flaws in the design of their study.
The first area of concern involves the route of cimetidine administration. Cimetidine was first administered intravenously for one dose and then orally every 6 hours for the next three doses. The difference in bioavailability between the oral and intravenous routes of
FRANK WO, SEAMAN JJ, PEACE KE, MYERSON RM, HUMPHRIES TJ. Lidocaine-Cimetidine Interaction. Ann Intern Med. ;99:414–415. doi: 10.7326/0003-4819-99-3-414_2
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Published: Ann Intern Med. 1983;99(3):414-415.
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