RICHARD GANNON, PHARM. D.; WENDY PEARSALL, R.N.; RICHARD ROWLEY, M.D.
To the editor: It has been postulated that there may be an interaction between meperidine and isoniazid (1). The theoretical basis of this interaction relates to inhibition of monoamine oxidase by isoniazid (2). The interaction between traditional inhibitors of monoamine oxidase and meperidine is well described. There is an immediate effect manifest by either excitation, diaphoresis, rigidity, and hypertension, or hypotension and central nervous system depression (3). We report an interaction where concurrent isoniazid and meperidine produced these effects.
A 54-year-old white man weighing 60 kg was admitted to the hospital with spiking temperatures (up to 40.5°C) and new bilateral
GANNON R, PEARSALL W, ROWLEY R. Isoniazid, Meperidine, and Hypotension. Ann Intern Med. ;99:415. doi: 10.7326/0003-4819-99-3-415_2
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Published: Ann Intern Med. 1983;99(3):415.
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