JOHN G. GERBER, M.D.
Whether prostaglandins have any role in the control of blood pressure is an issue that has been debated for many years. Ever since the isolation from the renal medulla of lipid-soluble vasodepressor substances that have properties similar to the then recently discovered prostaglandins, it has been suggested that renal prostaglandins may have a physiologically important antihypertensive effect (1, 2). The isolation of prostaglandin A2 from rabbit kidney medulla and the subsequent demonstration of the antihypertensive effect of intravenously administered prostaglandin A1 in humans seemed to corroborate a proposed role for prostaglandin A as a circulating vasodepressor substance responsible for lowering
GERBER JG. Indomethacin-Induced Rises in Blood Pressure. Ann Intern Med. ;99:555–558. doi: 10.7326/0003-4819-99-4-555
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Published: Ann Intern Med. 1983;99(4):555-558.
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