PETER J. SCHWARTZ, M.D.
Prolongation of the Q-T interval is associated with increased risk of sudden cardiac death (1), whether idiopathic (2), secondary to drugs and electrolyte imbalance (3), or associated with ischemic heart disease (4). The drugs more commonly associated with Q-T prolongation and ventricular fibrillation are quinidine, disopyramide, prenylamine, phenothiazine, and tricyclic antidepressants. Thioridazine probucol, Sotalol, procainamide, and encainide have also been associated with Q-T prolongation and malignant arrhythmias. The antiarrhythmic drug amiodarone is unique in that it prolongs the Q-T interval but, as this phenomenon is secondary to a uniform prolongation of all ventricular action potentials, the net effect is a
PETER J. SCHWARTZ. The Idiopathic Long Q-T Syndrome. Ann Intern Med. 1983;99:561–562. doi: 10.7326/0003-4819-99-4-561
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Published: Ann Intern Med. 1983;99(4):561-562.
Cardiology, Rhythm Disorders and Devices.
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