GEORGE S. HUGHES JR., M.D.
To the editor: Neftel and associates (1) and Miro and associates (2) have recently described several cases of penicillin-induced neutropenia. In both letters, high doses of methicillin, nafcillin, oxacillin, cloxacillin, and penicillin G have been reported to produce leukopenia. The incidence of induced neutropenia has been reported to be between 7% to 16%. With smaller doses of penicillin, the complication is extremely rare and has not been reported with ampicillin (1, 3). We report a case of neutropenia and thrombocytopenia secondary to administration of oral ampicillin.
A 30-year-old, white woman was admitted with a clinical diagnosis of pelvic inflammatory disease
HUGHES GS. Ampicillin and Hematologic Effects. Ann Intern Med. ;99:573. doi: 10.7326/0003-4819-99-4-573_1
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Published: Ann Intern Med. 1983;99(4):573.
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