R. OR, M.D.; Y. KLEINMAN, M.D.; T. CHAJEK-SHAUL, M.D.
To the editor: We write to report a urinary bladder tumor that developed with prolonged use of azathioprine in a young patient with systemic lupus erythematosus.
A 27-year-old man 12 years previously had had a skin rash, hepatosplenomegaly, Coombs' positive hemolytic anemia, and nephritis. A diagnosis of systemic lupus erythematosus was confirmed by a positive test for lupus erythematosus cells. Results of a kidney biopsy showed active focal proliferative and necrotizing lupus nephritis. The patient was treated with steroids and azathioprine. A complete clinical and laboratory remission was achieved, and the patient was maintained on prednisone, 20 mg/d, and azathioprine,
OR R, KLEINMAN Y, CHAJEK-SHAUL T. Azathioprine and Urinary Bladder Tumor. Ann Intern Med. ;99:737. doi: 10.7326/0003-4819-99-5-737_1
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Published: Ann Intern Med. 1983;99(5):737.
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