DAVID NICHOLSON, M.D.
To the editor: Halkin and associates (1) presented the results of a study purporting to show that low-dose heparin resulted in a 31. 1% reduction in mortality in patients admitted to a general medical service. The authors allow that their study was not double blind, and that treatment was allocated after "randomization" by odd and even hospital numbers, which was open to bias as shown by the higher number of contraindications identified in the "heparin" group. The hospital number was determined by a clerk in the emergency room, before evaluation for emergency admission, and a table of random numbers was
NICHOLSON D. Heparin Prophylaxis. Ann Intern Med. ;99:738. doi: 10.7326/0003-4819-99-5-738_1
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Published: Ann Intern Med. 1983;99(5):738.
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