J.R. TAGG, PH.D.; G. PETERS, M.D.; E.D. GRAY, PH.D.; L.W. WANNAMAKER, M.D.
To the editor: Although an etiologic association between toxic shock syndrome and vaginal colonization with Staphylococcus aureus is generally accepted as being beyond doubt, many questions regarding the pathogenesis of the syndrome remain unanswered. The ability of potentially pathogenic bacteria to colonize body surfaces may be enhanced by their production of inhibitory substances that restrict the growth of other bacteria (1). Evaluation of bacteriocin production by strains of S. aureus associated with toxic shock syndrome has been our primary interest. These proteinaceous antibiotic agents have inhibitory activity directed predominantly against other bacteria of either the same or closely-related species (2).
TAGG J, PETERS G, GRAY E, WANNAMAKER L. Bacterial Interference and Toxic Shock Syndrome. Ann Intern Med. ;99:879–880. doi: 10.7326/0003-4819-99-6-879_2
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Published: Ann Intern Med. 1983;99(6):879-880.
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