REBECCA S. MASON, M.B., Ph.D.; THERESA FRANKEL, B.V.Sc., Ph.D.; YUK-LUEN CHAN, M.B.; DIANNE LISSNER; SOLOMON POSEN, M.D.
Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from calcitriol, whereas six nonsarcoid lymph nodes failed to produce this compound.
MASON RS, FRANKEL T, CHAN Y, LISSNER D, POSEN S. Vitamin D Conversion by Sarcoid Lymph Node Homogenate. Ann Intern Med. ;100:59–61. doi: 10.7326/0003-4819-100-1-59
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Published: Ann Intern Med. 1984;100(1):59-61.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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