STAVROS C. MANOLAGAS, M.D., PH.D; LEONARD J. DEFTOS, M.D.
The importance of 1,25 dihydroxyvitamin D3 (calcitriol), the hormone formed from two hydroxylations of the parent vitamin D, on mineral and skeletal metabolism is well established. The mineralotropic effects of calcitriol are produced in the classic target organs of vitamin D: intestine, bone, and kidney. However, the identification of several additional target organs for calcitriol has shown that this hormone regulates many more tissues and that its role in biology extends far beyond its classically regarded role in mineral metabolism. A rapidly increasing body of evidence suggests that calcitriol is involved with the hematolymphopoietic tissue, and new theoretical and clinical
MANOLAGAS SC, DEFTOS LJ. The Vitamin D Endocrine System and the Hematolymphopoietic Tissue. Ann Intern Med. 1984;100:144–146. doi: 10.7326/0003-4819-100-1-144
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Published: Ann Intern Med. 1984;100(1):144-146.
Endocrine and Metabolism.
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