MYRON S. COHEN, M.D.; T. KENNEY GRAY, M.D.
To the editor: We read with interest the reports by Breslau and associates (1) and Mason and coworkers. (2) regarding vitamin D and its relationship to the hypercalcemia of lymphomas and of sarcoidosis. We have recently reported (3) that phagocytic cells including human neutrophils and monocytes metabolize calcifediol to three distinct metabolites. One of these peaks could easily be misidentified as calcitriol by several commonly used chromatographic systems. Perhaps this novel metabolite contributed to the mild elevations of calcitriol reported in the three patients with lymphoma (1).
The metabolism of calcifediol by a lymph node removed from a patient with
COHEN MS, GRAY TK. Cells Metabolizing Vitamin D. Ann Intern Med. ;100:611–612. doi: 10.7326/0003-4819-100-4-611_2
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Published: Ann Intern Med. 1984;100(4):611-612.
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