MYRON S. COHEN, M.D.; T. KENNEY GRAY, M.D.
To the editor: We read with interest the reports by Breslau and associates (1) and Mason and coworkers. (2) regarding vitamin D and its relationship to the hypercalcemia of lymphomas and of sarcoidosis. We have recently reported (3) that phagocytic cells including human neutrophils and monocytes metabolize calcifediol to three distinct metabolites. One of these peaks could easily be misidentified as calcitriol by several commonly used chromatographic systems. Perhaps this novel metabolite contributed to the mild elevations of calcitriol reported in the three patients with lymphoma (1).
The metabolism of calcifediol by a lymph node removed from a patient with
MYRON S. COHEN, T. KENNEY GRAY. Cells Metabolizing Vitamin D. Ann Intern Med. 1984;100:611–612. doi: 10.7326/0003-4819-100-4-611_2
Download citation file:
Published: Ann Intern Med. 1984;100(4):611-612.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use