VIJAY S. KUDESIA, M.D.
To the editor: I read the article by Dr. Kelton (1) with interest and found one statement questionable. Kelton wrote that "Only edetic-acid-anticoagulated capillary tubes should be used (not capillary tubes anticoagulated with heparin, because heparin causes platelet clumping and can result in a spuriously low platelet count)." In-vitro clumping of platelets resulting in a spuriously low count is one of the mechanisms of pseudothrombocytopenia; however, review of literature seems to implicate the presence of edetic acid in such a phenomenon (2). In this study platelet agglutination was seen in presence of edetic acid as well as penta-acetic acid and
KUDESIA VS. Choice of Platelet Anticoagulants. Ann Intern Med. ;100:613. doi: 10.7326/0003-4819-100-4-613_2
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Published: Ann Intern Med. 1984;100(4):613.
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